Regulatory Mechanisms and Pathophysiological Significance of IP3 Receptors and Ryanodine Receptors in Drug Dependence
نویسندگان
چکیده
منابع مشابه
IP3 receptors
What are they? Members of a family of intracellular ligand-gated ion channels that allow Ca2+ release from intracellular stores. The endoplasmic reticulum (ER), or specialised regions of it, contains ATP-driven Ca2+ pumps which generate a high Ca2+ concentration in the ER lumen. When inositol 1,4,5-trisphosphate (IP3) binds to IP3 receptors, the channel region of the receptor opens, allowing Ca...
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متن کاملHeterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles.
The roles played by ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP₃Rs) in vascular smooth muscle in the microcirculation remain unclear. Therefore, the function of both RyRs and IP₃Rs in Ca(²+) signals and myogenic tone in hamster cremaster muscle feed arteries and downstream arterioles were assessed using confocal imaging and pressure myography. Feed artery vascular ...
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Although pentazocine binds to σ1-receptor (σ1R) with high affinity, the physiological relevance of its binding remains unclear. We first confirmed that σ1R stimulation with pentazocine rescues contractile dysfunction following pressure overload (PO)-induced cardiac hypertrophy ovariectomized (OVX) female rats. In in vivo studies, vehicle, pentazocine (0.5-1.0 mg/kg ip), and NE-100 (1.0 mg/kg po...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2013
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.13r07cp